Polyhydroxylated fullerene (Fullerenols) / C60, -OH Functionalized
The starting material is >99% purity C60 fullerenes. C60 bearing over 40 hydroxyl groups that have higher water solubility (>50 mg/mL).
Polyhydroxylated fullerene (Fullerenols) / C60, -OH Functionalized
| Product Name | NRE-41010 |
| CAS | 99685-96-8 |
| Purity | >98% |
| Melting Point | >280 °C |
| Morphology | Spherical |
| Flash Point | > 94 °C |
| Density | 1.6 g/cm³ at 20 °C |
| Molecular Formula | C60 |
| Molecular Weight | 720.64 g/mol |
| Form | Crystalline powder |
| Orbital energy | HOMO 6.1-6.2 eV |
| Orbital energy | UMO 4.5 eV |
| Reactivity | Non Reactive/ Non Soluble |
| Stability | Completely Stable |
| Solubility | Soluble in organic solvents |
Polyhydroxylated fullerene (Research Grade Fullerenols): The starting material is >99% purity C60 fullerenes. C60 bearing over 40 hydroxyl groups that have higher water solubility (>50 mg/mL). These exist as monodisperse nanoparticles in water and have a valiant polishing effect. They exhibit superior antioxidant and anti-inflammatory properties.
Biomedical Applications
Drug Delivery:
Fullerenols are explored as nanocarriers for targeted drug delivery, particularly for hydrophobic drugs. The hydroxylated surface improves biological interaction, allowing the fullerenol molecule to encapsulate drugs and deliver them to specific tissues or organs in a controlled manner. Fullerenols can enhance bioavailability, solubility, and targeted release of therapeutic agents.
Gene Delivery:
Fullerenols can be used for gene delivery systems, where they can transport nucleic acids (such as DNA or RNA) into specific cells. The surface of fullerenols can be functionalized with targeting ligands, making them suitable for gene therapy or RNA interference (RNAi) applications. This makes fullerenols useful for genetic medicine, including treatments for genetic disorders.
Antioxidant Therapy:
Fullerenols are recognized for their potent antioxidant effects, neutralizing free radicals and reactive oxygen species (ROS). These properties make fullerenols valuable in the treatment of oxidative stress-related diseases like Alzheimer’s disease, Parkinson’s disease, stroke, and cardiovascular diseases. Fullerenols can protect cells and tissues from damage caused by oxidative stress.
Cancer Therapy:
Fullerenols are being studied for use in cancer therapy. The hydroxyl groups provide functional sites for attaching chemotherapeutic drugs or radioactive isotopes for targeted cancer therapy. Their ability to accumulate in tumor tissues and interact with cancerous cells makes them suitable for drug conjugation and nanomedicine applications.
Biosensing:
Fullerenols are being explored in biosensors for detecting biomolecules (e.g., proteins, DNA, RNA) or pathogens. Their surface properties allow for functionalization with bioreceptors, making them ideal for diagnostics and early disease detection. Fullerenol-based sensors can be used in detecting biomarkers for diseases such as cancer or infectious diseases.
Environmental Applications
Pollution Cleanup:
Fullerenols can help in environmental remediation by adsorbing and neutralizing heavy metals or organic pollutants from water or soil. Their high surface area and reactivity allow them to efficiently capture contaminants like lead, mercury, pesticides, and industrial waste.
Water Purification:
Fullerenols are being studied for their use in water purification systems. Their ability to adsorb toxic chemicals and pollutants makes them useful for removing contaminants from drinking water or wastewater. Fullerenols can be functionalized to enhance selectivity for specific contaminants, providing an efficient method for cleaning water.
